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Art Occult occult
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Art Occult occult Information
Androstenedione-the truth comes out
Androstenedione
entered the national spotlight in the summer of 1998, when
Baseball home run
record-holder Mark McGwire told reporters that he used
The supplement to
improve his performance. Since McGwire\'s admission a
Little more than 18
months ago, androstenedione use has increased 500%
According to a recent
press release by Barry McCaffrey, director of the
Office of National Drug
Control Policy.
Manufacturers claim that \"Andro,\" as the supplement is
commonly known,
Boosts the body\'s natural testosterone levels and increases
Muscle-building ability. Body-builders tout it as a natural alternative to
Anabolic steroids. Nevertheless, questions remain about the efficacy and
Safety of this widely available substance, which is currently unregulated
By the Food and Drug Administration (FDA).
Androstenedione is a
steroid hormone that is part of what is called the
Production pathway for
testosterone. Testosterone promotes muscle growth,
But it also increases
body hair, can cause acne, and enhances growth of
The prostate gland. Some
believe that higher levels may adversely affect
Cholesterol levels and
cardiovascular health.
Manufacturers claim that Andro boosts testosterone
levels, allowing
Weightlifters to increase muscle mass without resorting to
synthetic
Steroid injections. Andro is touted as \"natural\" because it is
normally
Made in the adrenal glands and testes. Anabolic steroids are
synthetic
Derivatives of testosterone not found in the body. In theory,
Andro
Supplements are converted to natural testosterone in the body.
Despite a lack of persuasive evidence that Andro can actually
Boost
muscle mass, the supplement has been heavily marketed
And is widely used by
athletes and body-builders.
Despite a lack of persuasive evidence that
Andro can actually boost muscle
Mass, the supplement has been heavily
marketed and is widely used by
Athletes and body-builders.
Nevertheless,
according to a study by Douglas S. King, PhD, and colleagues
At Iowa State
University, androstenedione does not appear to help build
Muscle or increase
blood testosterone levels. Published in the June 2,
1999, issue of the
Journal of the American Medical Association (JAMA), the
Study compared
testosterone levels in 20 young men who were on a moderate
8-week
muscle-training regimen. Half of the subjects received a daily
300-milligram
dose of androstenedione, while the other half received a
Placebo.
The
researchers found no difference from response to placebo, in either
Muscle
strength or muscle mass, in the men taking Andro. They also found
That blood
testosterone levels were not increased by the supplement.
Researchers did
note one difference in the men taking the supplement: They
Had a significant
elevation in of estrogen, a hormone associated with
Female body
characteristics.
Increased levels of estrogen have been linked to
gynecomastia (breast
Enlargement) in men and breast cancer in women,
according to the Iowa
Authors. They also found that men using
androstenedione had a significant
Decrease in blood levels of high-density
lipoprotein cholesterol (HDL),
The \"good\" cholesterol thought to help
fight the buildup of fatty plaques
On artery walls. In theory, then, use of
androstenedione may increase
Risks for cardiovascular disease.
Furthermore, research performed on rats, published in the July 1999 issue
Of Endocrinology, suggests that androstenedione may lead to increased
Aggression or \"steroid-induced rage\" in much the same way that
Testosterone does. And some researchers speculate that, as in the case of
Anabolic steroid use, excessive use of androstenedione may shut off the
Body's own production of testosterone and shrink the testicles. Finally,
Androgens in adolescents are known to stunt growth, so the supplement
Should not be used by teens that have not completed puberty.
Despite
these emerging concerns, androstenedione remains a readily
Available
over-the-counter nutritional supplement. Because the substance
Is
unregulated, the purity of commercially available androstenedione is
Unknown, and probably varies from manufacturer to manufacturer.
While
the National Baseball Association allows players to use the
Supplement,
several athletic organizations have banned its use, including
The National
Football League, the National Collegiate Athletic
Association, and the
International Olympic Committee.
In an accompanying editorial comment on
King\'s JAMA study, Dr. Charles
Yesalis II of Pennsylvania State University
notes a worrisome trend:
Increasingly widespread use of the supplement,
particularly among young
People. Several questions regarding safety and
efficacy remain to be
Answered. For example, King\'s study used a daily dose
of 300 milligrams,
But recent advertisements for androstenedione recommend a
daily dose of
500 to 1,200 milligrams. We know very little about side
effects at this
dosage.
The data on effectiveness also remain murky. For
instance, some believe
Andro may \"work better\" in better-trained athletes.
Most of the subjects
In King\'s study were relative newcomers to weight
training, and such
Inexperienced weight trainers generally make impressive
gains in the early
Phase of resistance training. Those gains could
overshadow, statistically,
Any potential benefit from androstenedione.
As Yesalis notes in his editorial, \"Future studies may need to focus on
The effects of a higher dose of androstenedione administered over a period
Longer than 8 weeks.\"
Dr. Yesalis concludes with a call for government
review of the supplement.
\"In the case of androstenedione,\" he writes,
\"the study by King et al
Contributes to the evidence suggesting that the
government should
Carefully consider intervening and remove androstenedione
and its
Derivatives from the market.\"
Meanwhile, in light of the
potential health hazards and lack of evidence
For androstenedione\'s
muscle-building power, consumers should proceed with
Caution and consult a
physician before traveling this largely unmarked
road.
ANDROS-D
(Andro) Ingredients: Each capsule contains Pure Micronzed Androstenedione -
100mg. Zinc - 15mg. Bioperine -
2.5mg. Suggested Use: Take 1-2 capsules
daily.
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